Biomarker Predicts How Prostate Cancer Will Respond to Chemotherapy

Prostate Cancer pic
Prostate Cancer
Image: webmd.com

Compassionate physician Dr. Matthew Taub has been working in the hematology and oncology field for more than two decades. A physician at Optimum Oncology Hematology Associates in Florida, he has treated several benign and malignant disorders over the course of his career. Committed to remaining apprised of developments in his field, Dr. Matthew Taub attends numerous professional meetings during the year.

In December 2018, cancer researchers from Australia discovered a biomarker that can predict how well patients with metastatic prostate cancer will respond to chemotherapy. Known as the mGSTP1 (glutathione s transferase gene) biomarker, researchers discovered the presence of this gene in the blood of more than 80 percent of patients with metastatic castration-resistant prostate cancer (mCRPC). Following two cycles of chemotherapy using docetaxel, the biomarker was not found in 53 percent of cases. This decrease in mGSTP1 was also associated with better overall survival rates and slower progression of the disease.

Scientists discovered that mGSTP1 was a biomarker for prostate cancer more than two decades ago. However, the current study was the first phase 3 investigation of how patients with this gene responded to chemotherapy. Although more research is needed, scientists feel that the discovery of how mGSTP1 responds to chemotherapy will help physicians better customize treatment based on the genetic makeup of a patient’s cancer. It will also hopefully lead to the development of the first epigenetic biomarkers for prostate cancer.

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